Explore
Home 
Literature 
Links 
Posts 
Molecules 
Blogs 
Zeitgeist 
Markup Help 
News 

Because the levers and cogs of Nature's machines are so thought provoking...

Most recent posts

G protein-coupled receptors are a very large superfamily of transmembrane proteins that transmit signals into cells. They all have seven membrane-spanning helices, and most of them can activate a so-called G-protein that binds guanine nucleotides. I say most...
In my last post, I mentioned how highly homologous TRP channels respond in opposite ways to temperature changes. A clue to this paradox came later, when the structure of TRPA1 was published by the same lab as the TRPV1 structure(1). The previously discussed...
How do we know when a room is hot or cold? The family of transient receptor potential (TRP) ion channels senses general stimuli such as temperature, reactive chemicals, and pH, which open a cation-conducting pore. In particular, one member called TRPV1 is a...

Most popular posts

G protein-coupled receptors are a very large superfamily of transmembrane proteins that transmit signals into cells. They all have seven membrane-spanning helices, and most of them can activate a so-called G-protein that binds guanine nucleotides. I say most...
In my last post, I mentioned how highly homologous TRP channels respond in opposite ways to temperature changes. A clue to this paradox came later, when the structure of TRPA1 was published by the same lab as the TRPV1 structure(1). The previously discussed...
How do we know when a room is hot or cold? The family of transient receptor potential (TRP) ion channels senses general stimuli such as temperature, reactive chemicals, and pH, which open a cation-conducting pore. In particular, one member called TRPV1 is a...