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Since December 2006, the Kilomentor Blog has appeared under the auspices of   the blogging site, Chemical Blogs. Starting to-day, all the Kilomentor blogs including the archives can be found at the new site www.kilomentor.com . Readers of the Kilomentor...
If Kilomentor is interested in a problem you introduce through a Kilomentor Comment and, so long as you are willing to have it examined in a public forum, my assessment in free. If I do not choose your problem to write about or if you want off-line, private,...
Using a more sophisticated method to recrystallize large amounts of   a process material can provide us a lot more information about the identity, quantity and solubility of the impurities present in that crude product. At the same time it quantifies the...

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What do I Mean by Catastrophic Failure. In the context used herein, I am defining a catastrophic failure of a process step trial as a very large loss of product quality or isolated yield from which there is no recovery. That is, by definition, there is no patch...
I have a confession to make at the very outset of this blog article. I have never performed a transfer hydrogenation in my entire career, even though I have been involved developing many hydrogenation process steps using hydrogen gas, often under pressure....
A topic that was much discussed at the recent Current Progress in Process Chemistry meeting in Princeton June 13-14th was enzyme catalysis of pharmaceutical process steps. Kilomentor has written about this subject before: http://kilomentor.chemicalblogs.com/55_kilomentor/archive/775_biocatalytic_methods_of_enantioselective_synthesis_in_pharmaceutical_process_development.html...

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Kilomentor has a fascinating post on "catastrophic failure" in the plant and goes on this interesting tangent about the dangers of scaling up a catalyzed reaction: The probability of catastrophic failure is increased for catalyzed reactions of which, for...
Kilomentor asks a good question -- why don't we use transfer hydrogenation?:...Transfer hydrogenation is here discussed as it relates to scaling up a hydrogenation step. Chemists who are more accustomed to working in the laboratory are overwhelmingly more familiar...
Kilomentor has an interesting post on the practicalities of running an enzymatic process (based on a process chemistry conference talk by Dr. Jacob Janey of BMS) -- specifically, now that you have an aqueous/organic slurry of product and enzyme, how the heck...