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This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.

Most recent posts

Our latest poll (please vote on the right-hand side of the page!) is about fragment libraries. Once you have your library, you can screen it using a variety of approaches. But what do you do once you get hits? Computational methods are increasingly being adopted;...
Ten years ago today Teddy launched Practical Fragments with a simple question about screening methodologies. More than 660 posts later we've returned to that topic several times, most recently in 2016. But before you can start screening you need a fragment...
Hard to believe we're already halfway through the year, but there are still some exciting events ahead, and 2019 is already starting to take shape.2018August 19-23: The 256th National Meeting of the American Chemical Society, which will be held in Boston, includes...

Most popular posts

Ten years ago today Teddy launched Practical Fragments with a simple question about screening methodologies. More than 660 posts later we've returned to that topic several times, most recently in 2016. But before you can start screening you need a fragment...
More mature readers may remember a column by Daedalus, aka David E. H. Jones, which used to run in Nature. Sadly he passed away last year, but his company, DREADCO, is still going strong. They have just launched a new product that should be of wide interest.Our...
Chirality underpins all life. Nineteen of the twenty amino acids contain at least one stereocenter, as do all nucelosides, sugars, and most metabolites. The very first fragment I ever found was chiral, but that is not typical, at least judged by those that...

Latest posts linking here

A list of small, useful things (links): The latest from Stellen fr ChemikerThe latest from All Things MetathesisFun post at Sustainable Nano about the chemistry of firefliesCongrats to See Arr Oh for pointing out errors in this paper on Xinghaiamine...
A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisDerek covers a paper (with an odd co-author) on the ability of chemists to predict highly-cited papersTh'Gaussling with some pretty cool picturesFunny...
A list of small, useful things (links):A new blog! Welcome to "The Compounds Turn." Nice first post on beets! Melanie Nelson is offering her "How to Get a Job In Industry" webinar on September 20. Great use of $30, I feel. Latest chemistry retractions...