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This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.

Most recent posts

The approved anti-cancer drug ibrutinib is a poster child for covalent modifiers, with projected 2018 sales of more than $1.2 billion. The molecule reacts with a cysteine residue in the kinase BTK as well as several other kinases, forming an irreversible bond....
Our current poll (please vote on the right-hand side of the page!) asks about commercial fragment libraries. However, there is much to be said about making your own fragments: you have total control over the quality, and it is easier to get into novel chemical...
A good fragment library is essential for generating good fragment hits. Earlier this year we asked about fragment size and library size, and summarized the results here.Some folks make their own fragments, but this is expensive, and its probably fair to say...

Most popular posts

This week thousands of chemists converged on the venerable city of Boston for the Fall National ACS meeting. One brief but rich symposium was entitled Best practices in fragment-based drug design, organized by Amy Hart, David Marcoux, and Heidi Perez (BMS).After...
Ten years ago today Teddy launched Practical Fragments with a simple question about screening methodologies. More than 660 posts later we've returned to that topic several times, most recently in 2016. But before you can start screening you need a fragment...
More mature readers may remember a column by Daedalus, aka David E. H. Jones, which used to run in Nature. Sadly he passed away last year, but his company, DREADCO, is still going strong. They have just launched a new product that should be of wide interest.Our...

Latest posts linking here

A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisPractical Fragments at ACS BostonTh'Gaussling writes wonderfully about life on a farmNice piece on Lab Without Benches about, among other...
A list of small, useful things (links): The latest from Stellen fr ChemikerThe latest from All Things MetathesisFun post at Sustainable Nano about the chemistry of firefliesCongrats to See Arr Oh for pointing out errors in this paper on Xinghaiamine...
A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisDerek covers a paper (with an odd co-author) on the ability of chemists to predict highly-cited papersTh'Gaussling with some pretty cool picturesFunny...