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This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.

Most recent posts

Proteins in cells are constantly synthesized and degraded in a complex, highly regulated manner managed in part by the ubiquitin proteasome system. Simplistically, a ubiquitous small protein called ubiquitin is conjugated to other proteins, targeting them for...
The enzyme lipoprotein-associated phospholipase A2 (Lp-PLA2) cleaves phospholipids into inflammatory molecules. As such, it has been pursued as a target for several indications, from atherosclerosis to Alzheimers disease. In 2016 we highlighted two fragment...
The new year has finally arrived, and brings quite a few interesting events.2018January 24: There will be a one-day FBLD workshop in Barcelona. This is part of FRAGNET, a European Commission training program for the next generation of fragment scientists. Registration...

Most popular posts

Chirality underpins all life. Nineteen of the twenty amino acids contain at least one stereocenter, as do all nucelosides, sugars, and most metabolites. The very first fragment I ever found was chiral, but that is not typical, at least judged by those that...
Practical Fragments has had quite a few posts on ligand efficiency (see here, here, and here, for starters). Ligand efficiency (LE) is defined simply as the free energy of binding for a ligand divided by the number of heavy atoms in the ligand. One of the criticisms...
Molecular complexity is a fundamental conceptunderlying fragment-based lead discovery: fragments, being simple, can bind to more sites on proteins and thus give higher hit rates than larger, more complex molecules. The ultimate example of this is water, which...

Latest posts linking here

A list of small, useful things (links):A new blog! Welcome to "The Compounds Turn." Nice first post on beets! Melanie Nelson is offering her "How to Get a Job In Industry" webinar on September 20. Great use of $30, I feel. Latest chemistry retractions...
A list of small, useful things (links):Ash on R.B. WoodwardA removal of an expression of concern for a paper at an RSC journal (via Retraction Watch)A retraction of a series of papers in ACS journals for incorrect coding (again, via Retraction Watch)Prof. Yudin...
A list of small, useful things (links):Fun travel post (chemistry-related) by Stuart CantrillAsh thinks the March for Science is important for industry scientistsAs a non-computationalist, this post at Practical Fragments on measures of molecular complexity...