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This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.

Most recent posts

Ligand deconstruction, in which a larger molecule is dissected into component fragments that are subsequently optimized, can be useful for developing new chemical series. This is nicely illustrated in a paper recently published in J. Med. Chem. by Kenneth Down...
Its been a while since the last installment in our getting misled series. One of the key issues with crystallography is that ligands are almost always modeled as binding in a single conformation. This does not necessarily reflect reality, as we discussed here....
Happy New Year! Lots of exciting events scheduled this year, many of them in the first half.March 20-22: Although not exclusively fragment-focused, the Sixth NovAliX Conference on Biophysics in Drug Discovery will have lots of relevant talks, and...

Most popular posts

This week thousands of chemists converged on the venerable city of Boston for the Fall National ACS meeting. One brief but rich symposium was entitled Best practices in fragment-based drug design, organized by Amy Hart, David Marcoux, and Heidi Perez (BMS).After...
Ten years ago today Teddy launched Practical Fragments with a simple question about screening methodologies. More than 660 posts later we've returned to that topic several times, most recently in 2016. But before you can start screening you need a fragment...
More mature readers may remember a column by Daedalus, aka David E. H. Jones, which used to run in Nature. Sadly he passed away last year, but his company, DREADCO, is still going strong. They have just launched a new product that should be of wide interest.Our...

Latest posts linking here

A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisPractical Fragments at ACS BostonTh'Gaussling writes wonderfully about life on a farmNice piece on Lab Without Benches about, among other...
A list of small, useful things (links): The latest from Stellen fr ChemikerThe latest from All Things MetathesisFun post at Sustainable Nano about the chemistry of firefliesCongrats to See Arr Oh for pointing out errors in this paper on Xinghaiamine...
A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisDerek covers a paper (with an odd co-author) on the ability of chemists to predict highly-cited papersTh'Gaussling with some pretty cool picturesFunny...