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Derek Lowes commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.

Most recent posts

I’ve written a couple of times over the years about the idea that Alzheimer’s disease might have an infectious component to it. That’s been proposed many times, but it’s fair to say that it’s never caught on. For one thing, the...
That didn’t take long. That didn’t take long at all. The federal “Right to Try” bill was just signed the other week, and we already have a company that’s willing – no, eager – to try it out. I will now cruelly caricature...
Pharmacokinetics – the study of how drugs are taken up, distributed, metabolized, and cleared – is obviously a key part of drug development. Every drug substance gets handled somewhat differently by the human body, and these differences can completely...

Most popular posts

Ask a chemist (I’ll do) about optical rotation, and you’ll get a confident answer about how right- and left-handed isomers of chiral compounds will rotate polarized light that shines through a solution of one of them. Ask one of us exactly how it...
Here’s a paper that will give many medicinal chemists a shiver of recognition. A group from Dundee reports a screening hit against the enzyme Ube2T, a ubiquitin-conjugating (E2) enzyme. For those outside the field, ubiquitin is indeed ubiquitous. It’s...
After years of work and untold amounts of money, Eli Lilly’s Alzheimer’s antibody, solanezumab, does not work. It does not help Alzheimer’s patients. No matter how many times you run the Phase III trials, or in which patient populations, they...

Latest posts linking here

A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisI found this Derek Lowe post about Lilly to be hilarious. YMMVFascinating post by Ash on science and faith.There are people who forge scientific...
A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisDerek covers a paper (with an odd co-author) on the ability of chemists to predict highly-cited papersTh'Gaussling with some pretty cool picturesFunny...
I'm sure everyone has read it already, but if you haven't read Derek's comments about depression and anxiety in graduate school (complete with his own story of late night failed experimental runs), you should. The last two paragraphs are worth quoting in full: ...I...