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Derek Lowes commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.

Most recent posts

Unfortunately, the Thanksgiving-to-Christmas season is a traditional one in the drug industry for layoffs and site closures. This is especially true for larger companies, who time these things more; smaller ones can hit the money wall at any time in the year....
I’m running a few days later than usual, but here’s this year’s list of medicinal chemistry books of interest. As in years past, thelist builds on previous recommendations, with updates and reader suggestions incorporated along the way.For...
There’s a rather large breakthrough in CRISPR gene editing – yeah, another one – that has downstream implications for drug discovery. A group at the Salk Institute reports in Cell that they’ve found a way to do both loss- and gain-of-function...

Most popular posts

After years of work and untold amounts of money, Eli Lilly’s Alzheimer’s antibody, solanezumab, does not work. It does not help Alzheimer’s patients. No matter how many times you run the Phase III trials, or in which patient populations, they...
When you screen a collection of compounds against a drug target, you have to be ready to deal with the fact that some fraction – and maybe it’s a large fraction – of the hit compounds are not really hits. They’re false positives of one...
Today’s blog post will be of interest mostly to US readers, since it concerns the US tax code. There has, of course, been a huge push recently for an overhaul of the tax system, with bills passing both the House and Senate. I am not, absolutely not, going...

Latest posts linking here

Hit-to-Lead optimisation is a crucial step in Drug Discovery. It implies the wise modification of hit molecules by following specific pharmacologic and pharmacokinetic parameters. Many strategies can be employed to tackle this challenge, one of them is bioisosterism....
A list of small, useful things (links):A great little story about the dislocation of the Great Recession from a former pharma scientist note: the site is political in natureMany of the jobs created since 2005 are temporaryRetraction Watch: Plse retract...
From Inside Higher Ed's Andrew Kreighbaum: The Senate early Saturday morning narrowly approved major tax legislation roundly opposed by higher education leaders and student groups... The 51-to-49 Senate vote sets up negotiations with House leaders...