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Derek Lowes commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.

Most recent posts

I had a book review recently in Nature, on a new volume (Thrifty Science) that looks over the history of early scientific experimentation from the viewpoint of its frugal nature – the idea of reusing and repurposing equipment, objects, and even rooms...
One would like to be able to reach into a cell and mess around with its functions in real time.Thanks to CRISPR and other gene-editing technologies, we can (more or less selectively) tweak individual genes, to a wide number of interesting effects. What if that...
I’ve written here about what I referred to as “nationalist science”, in that case actions by the Hungarian government against its own universities and the Chinese government’s vigorous promotion of traditional medicine. Now we can (unfortunately)...

Most popular posts

Ask a chemist (I’ll do) about optical rotation, and you’ll get a confident answer about how right- and left-handed isomers of chiral compounds will rotate polarized light that shines through a solution of one of them. Ask one of us exactly how it...
Here’s a paper that will give many medicinal chemists a shiver of recognition. A group from Dundee reports a screening hit against the enzyme Ube2T, a ubiquitin-conjugating (E2) enzyme. For those outside the field, ubiquitin is indeed ubiquitous. It’s...
After years of work and untold amounts of money, Eli Lilly’s Alzheimer’s antibody, solanezumab, does not work. It does not help Alzheimer’s patients. No matter how many times you run the Phase III trials, or in which patient populations, they...

Latest posts linking here

As has been widely publicised by now, 2018 was a good year for FDA novel drug approvals with no less than 59 listed. In this post, I will take a personal look at the PubChem CIDs as I have done for 2016  (but not 2017). In reverse chronological...
A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisInteresting thoughts on research by Jen HeemstraCool analysis of World Cup success and population size by Slava BernatTh'Gaussling on a...
A list of small, useful things (links): The latest from Stellen fr ChemikerThe latest from All Things MetathesisFun post at Sustainable Nano about the chemistry of firefliesCongrats to See Arr Oh for pointing out errors in this paper on Xinghaiamine...