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Derek Lowes commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.

Most recent posts

I like to say that when I was first working on G-protein coupled receptors (GPCRs) as drug targets, that after I while I thought I really understood a lot of what was going on. But that was the peak. Further experience eroded that confidence, and even though...
Let’s talk cell culture – specifically, how weird it is. There are an awful lot of ways to grow cells, naturally – different media of course, different scales, differences in how crowded you let them get, how often you split them, add nutrients,...
I learned the basics of organic synthesis some years ago (at the hands of the recently retired Tom Goodwin, which for those who know him will seem quite fitting). But the way I learned it is still pretty similar to the way that students are learning it now,...

Most popular posts

Ask a chemist (I’ll do) about optical rotation, and you’ll get a confident answer about how right- and left-handed isomers of chiral compounds will rotate polarized light that shines through a solution of one of them. Ask one of us exactly how it...
Here’s a paper that will give many medicinal chemists a shiver of recognition. A group from Dundee reports a screening hit against the enzyme Ube2T, a ubiquitin-conjugating (E2) enzyme. For those outside the field, ubiquitin is indeed ubiquitous. It’s...
After years of work and untold amounts of money, Eli Lilly’s Alzheimer’s antibody, solanezumab, does not work. It does not help Alzheimer’s patients. No matter how many times you run the Phase III trials, or in which patient populations, they...

Latest posts linking here

A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisInteresting thoughts on research by Jen HeemstraCool analysis of World Cup success and population size by Slava BernatTh'Gaussling on a...
A list of small, useful things (links): The latest from Stellen fr ChemikerThe latest from All Things MetathesisFun post at Sustainable Nano about the chemistry of firefliesCongrats to See Arr Oh for pointing out errors in this paper on Xinghaiamine...
The azide ion(N3) is one of those chemical entities that just plain looksweird.Three nitrogens in a row?checkTwo negative charges and a positive charge, for a net charge of 1 ?checkStable?check (as long as it’s treated gently).As it turns out, the azide...