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Derek Lowes commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.

Most recent posts

This is a good brief overview of a topic that’s becoming more important all the time: analysis on the single-cell level. And as the authors mention, it’s partly a case of wanting to do this, and partly a case of there being no other choice. Larger...
This piece in STAT is well worth a read. The author, Adam Rosenberg of Rodin Therapeutics, is ready to ditch rodent-centric models for human CNS disease, and I can see where he’s coming from. I’ve often said that when I think back on my Alzheimer’s...
I’m traveling today, but as I was scrolling through my RSS feeds on the plane (OK, yeah, I know, but they had free Wi-Fi and why not), I thought about how people of around my scientific generation, maybe a bit younger and certainly the older ones, often...

Most popular posts

Ask a chemist (I’ll do) about optical rotation, and you’ll get a confident answer about how right- and left-handed isomers of chiral compounds will rotate polarized light that shines through a solution of one of them. Ask one of us exactly how it...
Here’s a paper that will give many medicinal chemists a shiver of recognition. A group from Dundee reports a screening hit against the enzyme Ube2T, a ubiquitin-conjugating (E2) enzyme. For those outside the field, ubiquitin is indeed ubiquitous. It’s...
After years of work and untold amounts of money, Eli Lilly’s Alzheimer’s antibody, solanezumab, does not work. It does not help Alzheimer’s patients. No matter how many times you run the Phase III trials, or in which patient populations, they...

Latest posts linking here

As has been widely publicised by now, 2018 was a good year for FDA novel drug approvals with no less than 59 listed. In this post, I will take a personal look at the PubChem CIDs as I have done for 2016  (but not 2017). In reverse chronological...
A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisInteresting thoughts on research by Jen HeemstraCool analysis of World Cup success and population size by Slava BernatTh'Gaussling on a...
A list of small, useful things (links): The latest from Stellen fr ChemikerThe latest from All Things MetathesisFun post at Sustainable Nano about the chemistry of firefliesCongrats to See Arr Oh for pointing out errors in this paper on Xinghaiamine...