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Derek Lowes commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.

Most recent posts

I wrote here about the way that disordered proteins seem to be able to bind together tightly in the apparent absence of a defined structure, and along the way I expressed a desire not to lead any drug discovery efforts against such systems. Now here’s...
Regular readers will know that I have no problem believing that AI (in its various forms) will definitely have an impact on drug discovery. And regular readers will also know that I’m quite skeptical that it’s going to have an immediate impact on...
If you look at any collection of “common myths about cancer”, you will probably find reassurances about the idea that having cancer surgery might cause the cancer to spread to other parts of the body. I remember coming across this one some years...

Most popular posts

Ask a chemist (I’ll do) about optical rotation, and you’ll get a confident answer about how right- and left-handed isomers of chiral compounds will rotate polarized light that shines through a solution of one of them. Ask one of us exactly how it...
Here’s a paper that will give many medicinal chemists a shiver of recognition. A group from Dundee reports a screening hit against the enzyme Ube2T, a ubiquitin-conjugating (E2) enzyme. For those outside the field, ubiquitin is indeed ubiquitous. It’s...
After years of work and untold amounts of money, Eli Lilly’s Alzheimer’s antibody, solanezumab, does not work. It does not help Alzheimer’s patients. No matter how many times you run the Phase III trials, or in which patient populations, they...

Latest posts linking here

A list of small, useful things (links):The latest from Stellen fr ChemikerThe latest from All Things MetathesisDerek covers a paper (with an odd co-author) on the ability of chemists to predict highly-cited papersTh'Gaussling with some pretty cool picturesFunny...
I'm sure everyone has read it already, but if you haven't read Derek's comments about depression and anxiety in graduate school (complete with his own story of late night failed experimental runs), you should. The last two paragraphs are worth quoting in full: ...I...
Joyce, L. A.; Nawrat, C. C.; Sherer, E. C.; Biba, M.; Brunskill, A.; Martin, G. E.; Cohen, R. D.; Davies, I. W., Chem. Sci. 2018, 9, 415Contributed by Steven BacharachReposted from Computational Organic Chemistry with permissionThe structure of (+)-frondosin...