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Here's a really nice example of high-throughput reaction discovery/condition scouting from a team at Merck. They certainly state the problem correctly: Modern organic synthesis and especially transition metal catalysis is redefining the rules with which new...
I'm doing research today and tomorrow, but after that I'll be taking the rest of the week off, so blogging will be intermittent. Wednesday I'll be home making the traditional chocolate pecan pie (recipe here, with many helpful suggestions in......
I've written several times here about reaction discovery techniques, going back to 2011. And I've been meaning to link to this recent review in Nature Chemistry, because it's an excellent summary of the field and the relevant literature. If you're......

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After reading this piece on Chembark, I find that I have to help defend the whole chem-blogging enterprise. The latest Analytical Chemistry has an editorial from Royce Murray, on the subject. Unfortunately, it sounds like something written several years ago.......
As we approach October, Nobel Speculation Season is upon us again. And Ash is right at Curious Wavefunction - making the predictions gets easier every year, because you get to keep the lists you had from before, with maybe a......
I've had an interesting e-mail from a reader who wants to be signed as "Mrs. McGreevy", and it's comprehensive enough that I'm going to reproduce it in full below. As everyone but the editorial board of C&E; News has noticed,......

Latest posts linking here

Epigenetics is big.  Wicked big.  How big?  This big.  Papers come from everywhere.  In this paper, an academic group from Minnesota, goes after SIRT2 with fragments.  SIRT2 is a type III HDAC that resides primarily in the cytoplasm...
Derek Lowe has a link to a rather amusing inadvertent addition to a paper, John Spevacek has noted an equally amazing admission, but one that's on purpose. (2nd page, first paragraph)Tien Nguyen has written a really nice "successful assistant professor candidates...
For those of you following along at home, Retraction Watch has been covering the story of Wayne State professor Fazlul Sarkar. Thanks to anonymous commenters at PubPeer uncovering some obvious image manipulation issues, he's had a distinguished professor...