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Or as much of the inside as we're likely to have. Thanks to @AndyBiotech on Twitter, here's an SEC document detailing the negotiations between Merck and Cubist. It makes for interesting reading in general - you can see how a......
The clinical failure rate for disease-modifying Alzheimer's therapies remains perfect, unfortunately: a flat 100%. The latest news is from Roche. Their in-licensed amyloid-targeting antibody (gantenerumab, from MorphoSys) came up empty on an interim trial analysis....
Time to revisit an old favorite around here. Remember Nativis Pharmaceuticals? I do, since they provided one of my most treasured "you can expect legal action" letters. When last mentioned here, they were working on the "Voyager", a device (used......

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After reading this piece on Chembark, I find that I have to help defend the whole chem-blogging enterprise. The latest Analytical Chemistry has an editorial from Royce Murray, on the subject. Unfortunately, it sounds like something written several years ago.......
As we approach October, Nobel Speculation Season is upon us again. And Ash is right at Curious Wavefunction - making the predictions gets easier every year, because you get to keep the lists you had from before, with maybe a......
I've had an interesting e-mail from a reader who wants to be signed as "Mrs. McGreevy", and it's comprehensive enough that I'm going to reproduce it in full below. As everyone but the editorial board of C&E; News has noticed,......

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Fifteen years ago most people would have laughed at you if you told them kinase inhibitors would become such a big deal: the received wisdom at that point was that anything that competed with ATP for one kinase would just indiscriminately hit other kinases....
Epigenetics is big.  Wicked big.  How big?  This big.  Papers come from everywhere.  In this paper, an academic group from Minnesota, goes after SIRT2 with fragments.  SIRT2 is a type III HDAC that resides primarily in the cytoplasm...
Derek Lowe has a link to a rather amusing inadvertent addition to a paper, John Spevacek has noted an equally amazing admission, but one that's on purpose. (2nd page, first paragraph)Tien Nguyen has written a really nice "successful assistant professor candidates...