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The topic of phenotypic screening has come up around here many times, as indeed it comes up very often in drug discovery. Give your compounds to cells or to animals and look for the effect you want: what could be......
Yet another entry in the "Why do people keep investing in biopharma?" files. Take a look at the case of Puma Biotechnology. Their stock was as high as $140/share earlier in the year, and it gradually deflated to the high......
How many people working in the biopharma industry would jump to another company if they could? According to this survey, it's just over half: well above the average set by other industry sectors. The usual reasons are cited, in part......

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After reading this piece on Chembark, I find that I have to help defend the whole chem-blogging enterprise. The latest Analytical Chemistry has an editorial from Royce Murray, on the subject. Unfortunately, it sounds like something written several years ago.......
As we approach October, Nobel Speculation Season is upon us again. And Ash is right at Curious Wavefunction - making the predictions gets easier every year, because you get to keep the lists you had from before, with maybe a......
I've had an interesting e-mail from a reader who wants to be signed as "Mrs. McGreevy", and it's comprehensive enough that I'm going to reproduce it in full below. As everyone but the editorial board of C&E; News has noticed,......

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Last year we highlighted a paper in which fragments were attached to a warhead, a chemical group that could form a reversible covalent bond with cysteine residues in proteins. These fragments were then screened against a kinase to identify nanomolar inhibitors....
Last week, the internet (or at least a couple of people) were abuzz asking which elements have been used as elements. I decided to poll the lab for funsies - here's what everyone had to say.Read more...
When reading all the generic names for antibodies, is anyone else hearing them in Little Richard's voice? I'm pretty sure awopbopaloobop is in Phase II trials for small cell renal carcinoma, while Lilly is preparing alopbamboom for a NDA. ...