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I'm going to be taking an extra day of vacation before the kids start back to school, so I'm adding to the Labor Day weekend today. Blogging will resume on Tuesday, unless something gigantic happens before then. If I can......
Here's a short video history of the FDA, courtesy of BioCentury TV. The early days, especially Harvey Wiley and the "Poison Squad", are truly wild and alarming by today's standards. But then, the products that were on the market back......
A reader has sent along the question: "Have any repurposed drugs actually been approved for their new indication?" And initially, I thought, confidently but rather blankly, "Well, certainly, there's. . . and. . .hmm", but then the biggest example hit......

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After reading this piece on Chembark, I find that I have to help defend the whole chem-blogging enterprise. The latest Analytical Chemistry has an editorial from Royce Murray, on the subject. Unfortunately, it sounds like something written several years ago.......
As we approach October, Nobel Speculation Season is upon us again. And Ash is right at Curious Wavefunction - making the predictions gets easier every year, because you get to keep the lists you had from before, with maybe a......
I've had an interesting e-mail from a reader who wants to be signed as "Mrs. McGreevy", and it's comprehensive enough that I'm going to reproduce it in full below. As everyone but the editorial board of C&E; News has noticed,......

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Note: This article originally appeared in Nature Chemistry as part of their Blogroll section. You can see the original post here, though nothing was changed in its republication here, save for the postscript.Recent advertising strategies in which anti-science...
But in the meantime, a favorite story from Derek Lowe:There was, the story goes, a pork-pie company over in England that was producing huge numbers of the things. Huge, that is, compared to their number of employees. In fact, on closer inspection, they were...
Last year we highlighted a paper in which fragments were attached to a warhead, a chemical group that could form a reversible covalent bond with cysteine residues in proteins. These fragments were then screened against a kinase to identify nanomolar inhibitors....