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A longtime reader sent along this article, just based on the headline. "This headline triggers instant skepticism in me", he said, and I agree. "Potential to treat Alzheimer's" is both a bold and a weaselly statement to make. The weasel......
I've been thinking a lot recently about compound properties, and what we use them for. My own opinions on this subject have been changing over the years, and I'm interested to see if I have any company on this. First......
A recent computational paper that suggested that similarity to known metabolites could help predict successful drug candidates brought in a lot of comments around here. Now the folks at Cambridge MedChem Consulting have another look at it here. The big......

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After reading this piece on Chembark, I find that I have to help defend the whole chem-blogging enterprise. The latest Analytical Chemistry has an editorial from Royce Murray, on the subject. Unfortunately, it sounds like something written several years ago.......
As we approach October, Nobel Speculation Season is upon us again. And Ash is right at Curious Wavefunction - making the predictions gets easier every year, because you get to keep the lists you had from before, with maybe a......
I've had an interesting e-mail from a reader who wants to be signed as "Mrs. McGreevy", and it's comprehensive enough that I'm going to reproduce it in full below. As everyone but the editorial board of C&E; News has noticed,......

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Honestly, I don't have anything intelligent to add to this conversation. Derek Lowe has a nice post on it. Here's the official C&EN story, with a picture of the instrument in the living room where it was built.Until next year! ...
...and the carolers are already out. Thomson Reuters already have their 2014 Nobel Prize prediction list, and past tradition obliges me to respond. C&EN is also having a nice panel discussion on the prize at 3:30 PM EDT on September 29th, so if you...
The vast K-25 gaseous diffusion plant at Oak Ridge - anengineering endeavor (Image: Nuclear Secrecy Blog)Every once in a while you will find someone comparing a major scientific or technological challenge to the Manhattan Project - among such comparisons would...