New molecules
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teriflunomide
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ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...
This list of July USANs has been copied over (with thanks) from the ChEMBL blog to follow up a few things. I chose it because as small list I could quickly do three things 1) an (exact match) Google count of the name, 2) the same with the...
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This list of July USANs has been copied over (with thanks) from the ChEMBL blog to follow up a few things. I chose it because as small list I could quickly do three things 1) an (exact match) Google count of the name, 2) the same with the...
procaine
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I shall post occasionally on the concept of the “Scholarly Poor” people who need to read the scholarly literature and who can’t. “Can’t” == cannot afford the extortionate PayPerView (PPV) fees demanded by all publishers (all...
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Note: to celebrate the International Year of Chemistry 2011, there’s a blog carnival going on. This is my contribution. If you can’t follow the structural details, hopefully the story tells itself without the pictures. You can find the other entries...
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Conversion of carboxylic acid PMY 8-2 to the acid chloride using thionyl chloride and its subsequent coupling with glycolamide to give TCMDC-123812.Reaction start time: 16.20 EST 26/09/11PMY 8-2 (104 mg, 0.45 mmol, 1 equiv.) was dissolved in dry PhMe (5 mL)....
chlorin
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Chemical English, after all, is just a subset of English. As such, it suffers the same problem as English in general: the pronunciation of the words is far from obvious. What makes it worse for chemistry is absence of any authoritative pronunciation guide....
thiamine
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Chemical English, after all, is just a subset of English. As such, it suffers the same problem as English in general: the pronunciation of the words is far from obvious. What makes it worse for chemistry is absence of any authoritative pronunciation guide....
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Synthesis of ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate from condensation of 4-fluoroaniline with ethyl 2-acetyl-4-oxopentanoate.Experiment start time: 11.00 EST 20/09/11Ethyl acetoacetate (2.00 mL, 15.7 mmol, 1 equiv.) and K2CO3 (2.82 g,...
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Synthesis of ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate from condensation of 4-fluoroaniline with ethyl 2-acetyl-4-oxopentanoate.Experiment start time: 11.00 EST 20/09/11Ethyl acetoacetate (2.00 mL, 15.7 mmol, 1 equiv.) and K2CO3 (2.82 g,...
Posts
I did a double take when I saw the most recent offer to land in my inbox: “a $20 Brazilian Blow Dry”. I quickly realised it was a hair treatment wholly unrelated to waxing or any kind of sexual activity, but my being less than cranially hirsute,...
Forget the gruesome imagery on packets of cigarettes in the UK, the health campaigns, the nanny state warnings. There are seven simple reasons not to smoke cigarettes from a chemist’s perspective, each one is present at harmful levels in cigarette smoke:Benzene...