New molecules
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imatinib
Posts
Since the advent of imatinib, kinase inhibitors have become a thing in drug discovery, with more than two dozen already approved. Indeed, kinases are the targets of more than a third of reported fragment-derived compounds to reach the clinic. Given that all...
ChlorpromazinePsychiatric drugs have always been a black box. The complexity of the brain has meant that most successful drugs for treating disorders like depression, psychosis and bipolar disorder were discovered by accident and trial and error rather than...
Everyone's favorite free encyclopedia - wikipedia, has started to get links to ChEMBL added. The links are all sorted out, now we just need a bot to go round and sort everything out for a large set of compounds. So, to give you some idea of how it will look,...
bortezomib
Posts
The other day I was having a discussion with a colleague about the drug Velcade which has been used quite successfully to treat multiple myeloma. Velcade is probably the only bestselling drug that has the element boron in it. Boron is a highly reactive element...
Posts
The other day I was having a discussion with a colleague about the drug Velcade which has been used quite successfully to treat multiple myeloma. Velcade is probably the only bestselling drug that has the element boron in it. Boron is a highly reactive element...
carbonic acid
InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)
InChIKey=BVKZGUZCCUSVTD-UHFFFAOYSA
InChIKey=BVKZGUZCCUSVTD-UHFFFAOYSA
Posts
Lately we’ve been talking a lot about converting alcohols to good leaving groups [halides] [tosylates and mesylates] You might think we’d be done already, but not yet! In today’s post we talk about a third important method for converting alcohols...
neochlorogenic acid
InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14+,16-/m1/s1
InChIKey=CWVRJTMFETXNAD-NGZLMGFWSA
InChIKey=CWVRJTMFETXNAD-NGZLMGFWSA
Posts
First, the recipe.Making sloe gin really is as easy as 1, 2, 3… it only requires three ingredients (a fourth is optional) and the particular ratio my recipe uses is 1:2:3 (sugar:sloes:gin). The recipe is easily scaled depending on the size of the container...
caffeic acid
InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+
InChIKey=QAIPRVGONGVQAS-NGZLMGFWSA
InChIKey=QAIPRVGONGVQAS-NGZLMGFWSA
Posts
First, the recipe.Making sloe gin really is as easy as 1, 2, 3… it only requires three ingredients (a fourth is optional) and the particular ratio my recipe uses is 1:2:3 (sugar:sloes:gin). The recipe is easily scaled depending on the size of the container...
InChI=1S/C27H30O15.ClH/c1-9-19(32)21(34)23(36)26(39-9)38-8-18-20(33)22(35)24(37)27(42-18)41-17-7-12-14(30)5-11(28)6-16(12)40-25(17)10-2-3-13(29)15(31)4-10;/h2-7,9,18-24,26-27,32-37H,8H2,1H3,(H3-,28,29,30,31);1H/t9-,18+,19-,20+,21+,22-,23+,24+,26+,27+;/m0.
Posts
First, the recipe.Making sloe gin really is as easy as 1, 2, 3… it only requires three ingredients (a fourth is optional) and the particular ratio my recipe uses is 1:2:3 (sugar:sloes:gin). The recipe is easily scaled depending on the size of the container...
quercetin
InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
InChIKey=REFJWTPEDVJJIY-UHFFFAOYSA
InChIKey=REFJWTPEDVJJIY-UHFFFAOYSA
Posts
First, the recipe.Making sloe gin really is as easy as 1, 2, 3… it only requires three ingredients (a fourth is optional) and the particular ratio my recipe uses is 1:2:3 (sugar:sloes:gin). The recipe is easily scaled depending on the size of the container...
chrysanthemin
InChI=1S/C21H20O11.ClH/c22-7-16-17(27)18(28)19(29)21(32-16)31-15-6-10-12(25)4-9(23)5-14(10)30-20(15)8-1-2-11(24)13(26)3-8;/h1-6,16-19,21-22,27-29H,7H2,(H3-,23,24,25,26);1H/t16-,17-,18+,19-,21-;/m1./s1
InChIKey=YTMNONATNXDQJF-COLDYULTSA
InChIKey=YTMNONATNXDQJF-COLDYULTSA
Posts
First, the recipe.Making sloe gin really is as easy as 1, 2, 3… it only requires three ingredients (a fourth is optional) and the particular ratio my recipe uses is 1:2:3 (sugar:sloes:gin). The recipe is easily scaled depending on the size of the container...
peonidin-3-o-glucoside
InChI=1S/C22H22O11/c1-30-15-4-9(2-3-12(15)25)21-16(7-11-13(26)5-10(24)6-14(11)31-21)32-22-20(29)19(28)18(27)17(8-23)33-22/h2-7,17-20,22-23,27-29H,8H2,1H3,(H2-,24,25,26)/p+1/t17-,18-,19+,20-,22-/m1/s1Key: ZZWPMFROUHHAKY-OUUKCGNVSA-O
Posts
First, the recipe.Making sloe gin really is as easy as 1, 2, 3… it only requires three ingredients (a fourth is optional) and the particular ratio my recipe uses is 1:2:3 (sugar:sloes:gin). The recipe is easily scaled depending on the size of the container...