New molecules
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2,4-dinitrophenylhydrazine
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A convoluted extraction series.Change the limiting reagent.Distillation.Trituration / Sohxlet.Prolonged high vacuum treatment.Recrystallization.The bisulfite/DNPH trick (aldehydes only).Secondary reactions [1].HPLC.The next reaction in the series.[1] Protections,...
phorbol
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I originally started writing this post before Christmas but then lost the near-completed version with the death of my laptop. However, I recently found some old backups and decided to finish it up and put it online for your enjoyment. Have fun!---BRSM.Total...
Could plant extracts still surprise us? "Magical rainforest berry kills tumors with single injection" read last month's FiercePharma headline. The Guardian reinforced the hype, narrowing down the berry's source (Queensland, Australia) and the...
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Epigenetics is big. Wicked big. How big? This big. Papers come from everywhere. In this paper, an academic group from Minnesota, goes after SIRT2 with fragments. SIRT2 is a type III HDAC that resides primarily in the cytoplasm...
idelalisib
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ATC Code: L01XX47Wikipedia: IdelalisibChEMBL: CHEMBL2216870On July 23rd the FDA approved Zydelig (idelalisib, GS-1101), as an orally-delivered drug to treat patients with three types of blood cancers. Relapsed chronic lymphocytic leukemia (CLL) Relapsed...
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Practical Fragmentshas tried to publicize the dangers of pan-assay interference compounds, or PAINS. These compounds show up as nuisance hits in lots of assays. So what are we to make of a new paper in Curr. Opin. Microbiol. by Pooja Gopal and Thomas Dick,...
Posts
Practical Fragmentshas tried to publicize the dangers of pan-assay interference compounds, or PAINS. These compounds show up as nuisance hits in lots of assays. So what are we to make of a new paper in Curr. Opin. Microbiol. by Pooja Gopal and Thomas Dick,...
Posts
Practical Fragmentshas tried to publicize the dangers of pan-assay interference compounds, or PAINS. These compounds show up as nuisance hits in lots of assays. So what are we to make of a new paper in Curr. Opin. Microbiol. by Pooja Gopal and Thomas Dick,...
Posts
Practical Fragmentshas tried to publicize the dangers of pan-assay interference compounds, or PAINS. These compounds show up as nuisance hits in lots of assays. So what are we to make of a new paper in Curr. Opin. Microbiol. by Pooja Gopal and Thomas Dick,...
ethionamide
Posts
Practical Fragmentshas tried to publicize the dangers of pan-assay interference compounds, or PAINS. These compounds show up as nuisance hits in lots of assays. So what are we to make of a new paper in Curr. Opin. Microbiol. by Pooja Gopal and Thomas Dick,...
Posts
Practical Fragmentshas tried to publicize the dangers of pan-assay interference compounds, or PAINS. These compounds show up as nuisance hits in lots of assays. So what are we to make of a new paper in Curr. Opin. Microbiol. by Pooja Gopal and Thomas Dick,...