New molecules
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vemurafenib
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linked to by 1ATC code: L01XE15Wikipedia: Vemurafenib On the August 17th 2011, the FDA approved Vemurafenib (trade name:Zelboraf TM Research code: PLX-4032, RG-7204 and RO-5185426), a BRAF kinase inhibitor for the treatment of patients with unresectable or metastatic...
citric acid
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Scale up of PMY 1-4 from 3 mmol to 20 mmol scale.Experiment start time: 1751 EST 22/08/114-fluoroaniline (2.10 mL, 22.2 mmol, 1.1 equiv.) and 2,5-hexanedione (2.30 mL, 20.7 mmol, 1 equiv.) were heated to 130 C (oil bath temp.). After 14 hours (0805 EST) the...
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See also: Paal-Knorr Synthesis of 1-aryl-2,5-dimethyl Pyrrole Core (PMY 1-1)Paal-Knorr Synthesis of 1-aryl-2,5-dimethyl Pyrrole Core (PMY 1-2)Experiment start time: 11.55 EST 18/08/20114-fluoroaniline (94.7 L, 1 mmol, 1 equiv.) and 2,5-hexanedione (117.3 L,...
Scale up of PMY 1-4 from 3 mmol to 20 mmol scale.Experiment start time: 1751 EST 22/08/114-fluoroaniline (2.10 mL, 22.2 mmol, 1.1 equiv.) and 2,5-hexanedione (2.30 mL, 20.7 mmol, 1 equiv.) were heated to 130 C (oil bath temp.). After 14 hours (0805 EST) the...
Synthesis of the core pyrrole of TCMDC-123794 and TCMDC-123812 from the GSK Tres Cantos antimalarial dataset listed in ChEMBLdb NTD databaseCondensation of 4-fluoroaniline and 2,5-hexanedione to form 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole.Experiment start...
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A procedure for the synthesis of 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde by Vilsmeier-Haack formylation of 1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrole.DMF (5.0 mL) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride...
Oxidation of aldehyde to acid using Oxone (Potassium peroxymonosulfate).Reactions start time: 1600 EST 30/08/11PMY 2-3 (100 mg, 0.46 mmol, 1 equiv.) was dissolved in DMF (5 mL, 0.09 M). Oxone (105 mg, 0.69 mmol, 1.5 equiv.) was added. TLC at 60 mins and 16.5...
Formylation of 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole obtained in experiment PMY 1-4 .Experiment start time: 13.20 EST 22/08/11DMF (1.00 mL, 14.4 mmol, 14.4 equiv.) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride (0.12 mL, 1.3...
Scale up of PMY 2-2 to 10.5 mmol scale.Experiment start time: 1433 EST 29/08/11DMF (5.0 mL) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride (1.18 mL, 12.7 mmol, 1.2 equiv.) was added and the reaction stirred for 35 minutes. Reaction...
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A procedure for the synthesis of 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde by Vilsmeier-Haack formylation of 1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrole.DMF (5.0 mL) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride...
Formylation of 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole obtained in experiment PMY 1-4 .Experiment start time: 13.20 EST 22/08/11DMF (1.00 mL, 14.4 mmol, 14.4 equiv.) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride (0.12 mL, 1.3...
Scale up of PMY 2-2 to 10.5 mmol scale.Experiment start time: 1433 EST 29/08/11DMF (5.0 mL) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride (1.18 mL, 12.7 mmol, 1.2 equiv.) was added and the reaction stirred for 35 minutes. Reaction...
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See also: Paal-Knorr Synthesis of 1-aryl-2,5-dimethyl Pyrrole Core (PMY 1-1)Paal-Knorr Synthesis of 1-aryl-2,5-dimethyl Pyrrole Core (PMY 1-2)Experiment start time: 11.55 EST 18/08/20114-fluoroaniline (94.7 L, 1 mmol, 1 equiv.) and 2,5-hexanedione (117.3 L,...
Scale up of PMY 1-4 from 3 mmol to 20 mmol scale.Experiment start time: 1751 EST 22/08/114-fluoroaniline (2.10 mL, 22.2 mmol, 1.1 equiv.) and 2,5-hexanedione (2.30 mL, 20.7 mmol, 1 equiv.) were heated to 130 C (oil bath temp.). After 14 hours (0805 EST) the...
Synthesis of the core pyrrole of TCMDC-123794 and TCMDC-123812 from the GSK Tres Cantos antimalarial dataset listed in ChEMBLdb NTD databaseCondensation of 4-fluoroaniline and 2,5-hexanedione to form 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole.Experiment start...
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See also: Paal-Knorr Synthesis of 1-aryl-2,5-dimethyl Pyrrole Core (PMY 1-1)Paal-Knorr Synthesis of 1-aryl-2,5-dimethyl Pyrrole Core (PMY 1-2)Experiment start time: 11.55 EST 18/08/20114-fluoroaniline (94.7 L, 1 mmol, 1 equiv.) and 2,5-hexanedione (117.3 L,...
Scale up of PMY 1-4 from 3 mmol to 20 mmol scale.Experiment start time: 1751 EST 22/08/114-fluoroaniline (2.10 mL, 22.2 mmol, 1.1 equiv.) and 2,5-hexanedione (2.30 mL, 20.7 mmol, 1 equiv.) were heated to 130 C (oil bath temp.). After 14 hours (0805 EST) the...
Synthesis of the core pyrrole of TCMDC-123794 and TCMDC-123812 from the GSK Tres Cantos antimalarial dataset listed in ChEMBLdb NTD databaseCondensation of 4-fluoroaniline and 2,5-hexanedione to form 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole.Experiment start...
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Forget the gruesome imagery on packets of cigarettes in the UK, the health campaigns, the nanny state warnings. There are seven simple reasons not to smoke cigarettes from a chemist’s perspective, each one is present at harmful levels in cigarette smoke:Benzene...
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Forget the gruesome imagery on packets of cigarettes in the UK, the health campaigns, the nanny state warnings. There are seven simple reasons not to smoke cigarettes from a chemist’s perspective, each one is present at harmful levels in cigarette smoke:Benzene...
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Forget the gruesome imagery on packets of cigarettes in the UK, the health campaigns, the nanny state warnings. There are seven simple reasons not to smoke cigarettes from a chemist’s perspective, each one is present at harmful levels in cigarette smoke:Benzene...