New molecules
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sucralose
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Most winters Punxatawney Phil is the furry face of Pennsylvania, but this year, he's got competition: meet the purple squirrel of Jersey Shore (which should not be confused with either a television show or a town in New Jersey). The news report offers a number...
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DMF (5.0 mL) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride (1.18 mL, 12.7 mmol, 1.2 equiv.) was added and the reaction stirred for 25 minutes. A solution of pyrrole PMY 1-6 (2.00 g, 10.5 mmol, 1 equiv.) in DMF (5 mL) was added...
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DMF (5.0 mL) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride (1.18 mL, 12.7 mmol, 1.2 equiv.) was added and the reaction stirred for 25 minutes. A solution of pyrrole PMY 1-6 (2.00 g, 10.5 mmol, 1 equiv.) in DMF (5 mL) was added...
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Grasping the abstract models chemists use to understand what holds a molecule together its bonding is one of the major goals of the general chemistry course I am teaching this semester. Understanding the bonding in a molecule is the key to...
I was away at a conference last week. One of those great small conferences where you can spend a lot of time interacting with people outside of the talks. It was great. I'm convinced the best science is discussed over beer and wine. I titled this blog post...
perampanel
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ATC Code: N03AX22Wikipedia: Perampanel On October 22nd 2012 the FDA approved Perampanel (research code: E2007, ER-155055-90, trade name Fycompa, CHEMBL1214124). Perampanel is an orally administered drug to be used as an adjunctive therapy for the treatment...
leflunomide
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ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...
fingolimod%20
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ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...
teriflunomide
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ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...
This list of July USANs has been copied over (with thanks) from the ChEMBL blog to follow up a few things. I chose it because as small list I could quickly do three things 1) an (exact match) Google count of the name, 2) the same with the...
glatiramer acetate
InChI=1/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8
InChIKey=FHEAIOHRHQGZPC-LIWUBZMANA
InChIKey=FHEAIOHRHQGZPC-LIWUBZMANA
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ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...
mitoxantrone
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ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...