New molecules
To have your blog items show up on this page, use the semantic markup for InChI's and SMILES, using microformats or RDFa. For example, write <span class="chem:smiles">CCCOC<span> instead of just CCCOC, or <span class="chem:inchi">InChI=1/bla<span> instead of InChI=1/bla.
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ATC Code: L01XX Wikipedia: CarfilzomibOn July 20th 2012 the FDA approved Carfilzomib (KyorolisTM) for the treatment of patients with multiple myeloma who have received prior therapies including bortezomib and an immunomodulatory therapy, and who have demonstrated...
aciclovir
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HIV reverse transcriptase is the target of aciclovir easy to say and its sort of correct - its the sort of statement that in the vernacular of drug discovery, most people would accept without the blink of an eye. This sentence strikes at the core of the concept...
adenosine triphosphate
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Organophosphates are a class of chemical compounds that possess a phosphate atom bound to a couple of oxygen atoms. They include among their ranks such essential-for-life biochemicals as nucleic acids and ATP, as well as life-ending insecticides, herbicides,...
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Everyone's favorite free encyclopedia - wikipedia, has started to get links to ChEMBL added. The links are all sorted out, now we just need a bot to go round and sort everything out for a large set of compounds. So, to give you some idea of how it will look,...
Ah, sildenafil. What more is there to say? It has saved marriages. Broken up marriages. Provided fodder for terrible comedians. Made spam just that much more intolerable.It works as follows. You swallow a pill, which breaks down in your stomach and intestine,...
A reminder of an on campus, open, seminar from Andy Bell (now at Imperial College), detailing the discovery and development of UK-92,480 (also known as sildenafil and even better known as V1agra and R3vat10). Andy was one of the medicinal chemists...
lorcaserin
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ATC Code: A08A (incomplete)Wikipedia: Lorcaserin On June 27th, the FDA approved Lorcaserin hydrochloride (Tradename: BelviqTM; Research Code: APD-356), a selective serotonin 2C receptor (5HT2c) agonist, for chronic weight management in adults with an initial...
serotonin
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ATC Code: A08A (incomplete)Wikipedia: Lorcaserin On June 27th, the FDA approved Lorcaserin hydrochloride (Tradename: BelviqTM; Research Code: APD-356), a selective serotonin 2C receptor (5HT2c) agonist, for chronic weight management in adults with an initial...
dexfenfluramine
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ATC Code: A08A (incomplete)Wikipedia: Lorcaserin On June 27th, the FDA approved Lorcaserin hydrochloride (Tradename: BelviqTM; Research Code: APD-356), a selective serotonin 2C receptor (5HT2c) agonist, for chronic weight management in adults with an initial...
armodafinil
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So some very sad news yesterday - the announcement of the closure of the Nutley R&D facilities of Roche. Families disrupted, kids moved to new schools, partners careers affected, and then inevitable greater competition for the few remaining jobs and downward...
phenoxymethylpenicillin
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Drug informatics can seem somewhat abstract until it translates to direct experience. Spending ~ 20 hours zonked out with a bacterial infection forcibly brings this home. This was my second encounter with septicemia the first being some years ago,...
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Drug informatics can seem somewhat abstract until it translates to direct experience. Spending ~ 20 hours zonked out with a bacterial infection forcibly brings this home. This was my second encounter with septicemia the first being some years ago,...