New molecules
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inositol
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Just about every chemistry blogger—including me—has lamented the increase in the number of businesses that advertise their products as “chemical free”. This rampant war on chemicals is as distressing to our field as it is to common sense—no...
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Just about every chemistry blogger—including me—has lamented the increase in the number of businesses that advertise their products as “chemical free”. This rampant war on chemicals is as distressing to our field as it is to common sense—no...
lsd
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Its been quite a year for the NBA All-Star: claiming his first NBA Championship, winning gold in the 2012 London Olympics, and nowpromoting dietary supplements?The product in question, Sheets, offers variations on the breath strips made popular roughly a decade...
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Conversion of PMY 59-2-B oxazole carboxylic acid (impure) to primary amide via reaction of the acid chloride with ammonia.Reaction Start Time: 11.55 13/08/12PMY 59-2-B (28 mg, 0.09 mmol, 1 equiv.) was stirred in PhMe (0.6 mL). Thionyl chloride (0.05 mL, 0.7...
aclidinium
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ATC Code: R03BB05Wikipedia: Aclidinium bromide On July 23th, the FDA approved Aclidinum bromide (Tradename: Tudorza PressairTM; Research Codes: LAS-34273, LAS W-330), a muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment...
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A US Army base in Utah was locked down for some time on Wednesday, because they discovered that they (transiently) misplaced a container of VX – a potent chemical weapon. Like they used in The Rock!A neurotransmitter called acetylcholine (or ACh) helps...
ATC Code: R03BB05Wikipedia: Aclidinium bromide On July 23th, the FDA approved Aclidinum bromide (Tradename: Tudorza PressairTM; Research Codes: LAS-34273, LAS W-330), a muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment...
tiotropium
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ATC Code: R03BB05Wikipedia: Aclidinium bromide On July 23th, the FDA approved Aclidinum bromide (Tradename: Tudorza PressairTM; Research Codes: LAS-34273, LAS W-330), a muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment...
Another GPCR structure! - this time the Rat muscarinic M3 receptor, published in Nature, complexed with the drug tiotropium (CHEMBL1201307). 10 20 30 40 50 4dajA ( 64 ) iwqvvfiafltgflAlvTiigNilVivAFkvnkqLktvnnyFllSLAcAD aaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 333...
ipratropium bromide
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ATC Code: R03BB05Wikipedia: Aclidinium bromide On July 23th, the FDA approved Aclidinum bromide (Tradename: Tudorza PressairTM; Research Codes: LAS-34273, LAS W-330), a muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment...
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Sometime before dawn this morning, we took our oldest son to the airport. He's bound for the Caribbean for a pre-orientation trip for college (learning to sail with a team of other freshmen). They will get the chance to do a little snorkeling, but when his...
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ATC Code: L01XX Wikipedia: CarfilzomibOn July 20th 2012 the FDA approved Carfilzomib (KyorolisTM) for the treatment of patients with multiple myeloma who have received prior therapies including bortezomib and an immunomodulatory therapy, and who have demonstrated...