New molecules
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teriflunomide
Posts
ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...
This list of July USANs has been copied over (with thanks) from the ChEMBL blog to follow up a few things. I chose it because as small list I could quickly do three things 1) an (exact match) Google count of the name, 2) the same with the...
glatiramer acetate
InChI=1/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8
InChIKey=FHEAIOHRHQGZPC-LIWUBZMANA
InChIKey=FHEAIOHRHQGZPC-LIWUBZMANA
Posts
ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...
mitoxantrone
Posts
ATC Code: L04AA13Wikipedia: Teriflunomide On September 12th the FDA approved Teriflunomide (tradename AUBAGIO, ChEMBL973), an orally administered drug for the treatment of relapsing forms of Multiple Sclerosis (MS). Teriflunomide is an inhibitor of of pyrimidine...
inositol
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Just about every chemistry blogger—including me—has lamented the increase in the number of businesses that advertise their products as “chemical free”. This rampant war on chemicals is as distressing to our field as it is to common sense—no...
Posts
Just about every chemistry blogger—including me—has lamented the increase in the number of businesses that advertise their products as “chemical free”. This rampant war on chemicals is as distressing to our field as it is to common sense—no...
lsd
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Its been quite a year for the NBA All-Star: claiming his first NBA Championship, winning gold in the 2012 London Olympics, and nowpromoting dietary supplements?The product in question, Sheets, offers variations on the breath strips made popular roughly a decade...
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Conversion of PMY 59-2-B oxazole carboxylic acid (impure) to primary amide via reaction of the acid chloride with ammonia.Reaction Start Time: 11.55 13/08/12PMY 59-2-B (28 mg, 0.09 mmol, 1 equiv.) was stirred in PhMe (0.6 mL). Thionyl chloride (0.05 mL, 0.7...
aclidinium
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ATC Code: R03BB05Wikipedia: Aclidinium bromide On July 23th, the FDA approved Aclidinum bromide (Tradename: Tudorza PressairTM; Research Codes: LAS-34273, LAS W-330), a muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment...
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A US Army base in Utah was locked down for some time on Wednesday, because they discovered that they (transiently) misplaced a container of VX – a potent chemical weapon. Like they used in The Rock!A neurotransmitter called acetylcholine (or ACh) helps...
ATC Code: R03BB05Wikipedia: Aclidinium bromide On July 23th, the FDA approved Aclidinum bromide (Tradename: Tudorza PressairTM; Research Codes: LAS-34273, LAS W-330), a muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment...
tiotropium
Posts
ATC Code: R03BB05Wikipedia: Aclidinium bromide On July 23th, the FDA approved Aclidinum bromide (Tradename: Tudorza PressairTM; Research Codes: LAS-34273, LAS W-330), a muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment...
Another GPCR structure! - this time the Rat muscarinic M3 receptor, published in Nature, complexed with the drug tiotropium (CHEMBL1201307). 10 20 30 40 50 4dajA ( 64 ) iwqvvfiafltgflAlvTiigNilVivAFkvnkqLktvnnyFllSLAcAD aaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 333...