linked to by 1 published by Science on Fri 22nd Jun 18 Eric Augier, Estelle Barbier, Russell S Dulman, Valentina Licheri, Ga??lle Augier, Esi Domi, Riccardo Barchiesi, Sean Farris, Daniel N??tt, R Dayne Mayfield, Louise Adermark, Markus Heilig
Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which ~15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the ??-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder.
If this works out, it’s something that people have been trying to find for a long time: what exactly are the genetic/biochemical vulnerabilities that make a person susceptible to alcoholism? It’s long been suspected that there must be some, but...
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