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The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer. The RuAAC reaction has quickly found its way into the organic chemistry toolbox and found applications in many different areas, such as medicinal chemistry, polymer synthesis, organocatalysis, supramolecular chemistry, and the construction of electronic devices. This Review discusses the mechanism, scope, and applications of the RuAAC reaction, covering the literature from the last 10 years.

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J. Mol. Model. instructions for authors clearly state, in the section on Ethical responsibilities of authors that Proper acknowledgements to other works must be given (this includes material that is closely copied (near verbatim), summarized and/or paraphrased),...
J. Mol. Model. instructions for authors clearly state, in the section on Ethical responsibilities of authors that Proper acknowledgements to other works must be given (this includes material that is closely copied (near verbatim), summarized and/or paraphrased),...