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The publication that I wanted to discuss was bought to my attention whilst reading Derek Lowe’s superb blog in the Pipeline. I would wholeheartedly recommend readers of this particular website to read the original blog discussion of the publication there....
Much of the early work of fragment screening involves avoiding artifacts. For high-concentration assays, compound purity is absolutely essential. However, this is not always easily assessed, as demonstrated in a recent paper in J. Med. Chem. by Alessio Ciulli,...
A friend in the business called my attention to this paper, which is about another piece of the ubiquitination system that I was writing about here just the other day – in this case, the deubiquitinating enzyme Rpn11. There are a couple of classes of...