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Experienced drug discovery folks, particularly those that work early on in the process, will tell you that aggregation is one of the most common sources of false positive “hits”. This happens when the molecule in question bunches up with others...
This recent paper asks the question “Can Invalid Bioactives Undermine Natural-Product Based Drug Discovery?” And as any of you who’ve done any natural product screening can attest, the answer is “You betcha”. There are any number...
Derek Lowe has blogged about our recent paperhttp://blogs.sciencemag.org/pipeline/archives/2015/09/30/aggregators-are...and there are some nice comments from the community. -- John...
Practical Fragments has quite a few posts about PAINS, or pan-assay interference compounds. In part this reflects their sad prevalence in the literature, but its also fair to say that they are easy targets because many are readily recognizable. But not all...